PROJEKTI
   

Project
Acronym: EUROSPAN 
Name: EUROpean special populations research Network: quantifying and harnessing genetic variation for gene discovery 
Project status: From: 2006-03-01 To: 2009-02-28 (Completed)
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Type (Programme): FP6 
Instrument: STREP 
Project cost: -
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Project coordinator
Organisation Name: THE UNIVERSITY OF EDINBURGH 
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Organisation country: Velika Britanija 
Contact person name: CAMPBELL, Harry 
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Croatian partner
Organisation name: Medicinski fakultet 
Organisation address:  
Contact person name: Rudan, Igor
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Contact person e-mail: Email 
Partners
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Short description of project
This project will study 5 special populations throughout Europe, which represent a unique resource for genomic research. It will quantify genetic variation in genes known to be involved in health and disease and will harness this variation to identify novel variants. The project will build on the achievements of substantial existing investment in these special populations and will pool expertise across Europe in phenotyping, genotyping, statistical genetics and social and ethical aspects of genomic research. A common database of health and disease-related phenotypes will be established and cores of expertise established in the major project areas. This will create the largest database of phenotypic and genotypic data from genetic isolate populations and thus will improve European competitiveness in gene discovery. The project will also provide the platform for the evaluation of a novel gene discovery approach (hybrid identity profiling), which has been developed by a European SME. Study objectives include: to describe the variation in allele frequencies in genetic variants involved in health or disease states. To harmonise existing health and disease-related phenotype data and reach agreement on genotyping procedures; and to adopt standard definitions, measurement methods and common data storage formats to form a common study database. To evaluate a novel European technology developed by IntegraGen (SME) for discovery of novel genetic variants to undertake an extended pedigree based genome-wide linkage analysis to identify quantitative trait loci (QTL) underlying a large number of traits, which underlie many of the main diseases of public health importance in Europe. Cross population mapping methods will be employed in fine mapping. To develop new statistical methods for pedigree based linkage analysis in these special populations. To define a best approach for dealing with related ethical and social issues in these populations. 
Short description of the task performed by Croatian partner
  


   

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