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Today there is no profession or field of human endeavor in which in some way does not mention environmental protection. The reason is the rapid industrial and technological progress which on the one hand contributes to a better quality of human life, but at the same time come up with incalculable consequences for the environment and human health as a result of this progress. In recent decades, scientists have become increasingly aware of the fact that many industrial products cause disease and make irreversible damage to the environment. Such products are named like "new contaminants." They are used in everyday life already, but on their effect on the environment, particularly in animals and humans over a long period of time it is known very little. In this type of contaminants include personal hygiene products, surfactants, various types of additives and colors, and pharmaceuticals. For most of these products, especially pharmaceuticals, and their active substances not known their actions after use, as well as the maximum allowable concentration in the environment, and often unavailable data on their physical and chemical properties. Laws partly determine their maximum allowable concentration in food (honey, meat, baby food), but the concentrations in water, soil and sediment are not yet defined. The main problem is that every day hundreds of new synthesized compounds particularly pharmaceuticals are continuously introduced into the environment due to the very high use either in human or in veterinary medicine. Their removals from various industrial and municipal waste water are impossible to classical physical-chemical-biological methods, and thus end up in the environment. However, in order to develop analytical methods for tracking pharmaceuticals in the environment it is necessary to know the physical and chemical properties of pharmaceuticals, and how we dispose of it again depends on their ecotoxicity to the environment. However, it is these data are very flawed and largely inaccessible, or are based on theoretical calculations based on the molecular structure of the investigated compounds (QSAR, EPIWEB 4.0), which is often inconsistent with experimental results. Therefore, the aim of this project to determine the ecotoxicity and physico-chemical properties of pharmaceuticals that are often used in human and veterinary medicine, but which are produced in pharmaceutical companies in Croatia and Slovenia. Investigated pharmaceuticals are from the group of antibiotics, anthelmintic, anesthetics, cytostatics, antidepressants and glucocorticoids. Ecotoxicity of pharmaceuticals will be examined in Vibrio fischeri bacteria with will determine both acute and chronic toxicity (short-term and long-term 30 min 24 h). Knowledge of the physical and chemical constants such as solubility of pharmaceuticals in water (s, mg / L), partition coefficient octanol/water or lipophilicity (Kow), acid ionization constants in aqueous solutions (Kk) facilitate access to experimental work, such as preparation of samples (water, sediment, soil), the development of analytical (chromatography) method, but also the identification and determination of pharmaceuticals in the environment. These physical-chemical parameters were determined to spectrometric and chromatographic methods, and capillary electrophoresis. The ultimate goal is to update our database of pharmaceuticals that occurred during the UKF international project "Reduction of environmental risk posed by pharmaceuticals and their degradation products in process wastewaters, through RO/NF membrane treatment (REPHAD)" which is available on the website (www.fkit .hr / UKF). The database will be used to assess the environmental impact of pharmaceutical residues, and can be used as a basis for future risk assessment of pharmaceuticals in the environment. Results of the proposed research are also of economic importance, since they can provide crucial guidance in the development of effective and financially viable technologies for water treatment loaded with persistent organic pollutants, such as pharmaceuticals.
Short description of the task performed by Croatian partner
a) The final goal is to update our database of pharmaceuticals which was created during the UKF international project "Reduction of environmental risk posed by pharmaceuticals and their degradation products in process wastewater, through RO/NF membrane treatment (REPHAD)" (www.fkit.hr/UKF).
b) With the proposed bilateral project we want to achieve and consolidate cooperation with mutual visits of researchers and scientists from Slovenia and Croatian.
Ovo web sjedište koristi tehnologiju "kolačića" (eng. cookie) da bi se korisnicima prikazao dinamičan i personaliziran sadržaj, te su oni nužni za ispravan rad. Ako nastavite pregledavati ove stranice, kolačići će biti korišteni u suradnji s vašim preglednikom Weba.
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